15 Key Bible Verses About Prayer: Prayer is the Key

Prayer is the key Bible verses

Are your prayers weak, ineffective, and leaving you feeling like you’re being ignored? Do you wonder if you could be doing it wrong or find yourself asking if it even works?

Fortunately, God is perfect so the problem is always within us. Let’s see what He says about unlocking prayer from key verses in the Bible.

We see many instances where God hears and responds to the cries of His people in Scripture, but His answers may not always align with our expectations.

Sometimes He says yes, sometimes He says no, and sometimes He says wait.

It’s important to trust that God’s perspectives are eternal. And even when we don’t understand His response, we can still be confident that He always works for our ultimate good.

Prayer is the Key for Answers in 15 Verses

1) Philippians 4:6-7 – Beg with Joy

Be anxious for nothing, but in everything by prayer and supplication with thanksgiving let your requests be made known to God. And the peace of God, which surpasses all comprehension, will guard your hearts and your minds in Christ Jesus.

Philippians 4:6-7 (NASB)

Taking pleasure in the Lord, meditating on His Word, and gratitude to God are antidotes to anxiety and worry. Doing so will lead to inner calm.

God says that He will keep watch over your entire inner person in ways that you cannot understand.

Our job is to fully believe that God is capable and willing to do what is best for us.

2) Matthew 6:9-13 – Submit to God

Pray then, in this way: ‘Our Father who is in heaven, Hallowed be Your name. Your kingdom come, Your will be done, On earth as it is in heaven. Give us this day our daily bread. And forgive us our debts, as we also have forgiven our debtors. And do not lead us into temptation, but deliver us from evil. [For Yours is the kingdom and the power and the glory forever. Amen.’]

Matthew 6:9-13 (NASB)
  • Prayer can be simple and brief.
  • You can petition God and human needs.
  • Our prayers must submit to God’s purposes and glory.
  • We’re supposed to ask God to forgive our spiritual debts or sins.
  • We should ask God to provide us a way through our trials and tribulations.
The power of prayer

3) 1 Thessalonians 5:16-18 – Have an Eternal Perspective

Rejoice always; pray without ceasing; in everything give thanks; for this is God’s will for you in Christ Jesus.

1 Thessalonians 5:16-18 (NASB)

Looking beyond our physical deaths with an eternal perspective should bring us continuous joy.

To pray without ceasing is telling us that we should continue to pray through the good times and through the bad times too. It means that we should pray in spite of difficult situations.

True believers are thankful for what Christ has done for us regardless of our situations. This can be easier said than done, but points to an eternal perspective–death is not the end for us.

4) James 5:16 – Be Honest & Open

Therefore, confess your sins to one another, and pray for one another so that you may be healed. The effective prayer of a righteous man can accomplish much.

James 5:16 (NASB)

Mutual honesty and openness is what allows believers to support each other spiritually. So let’s be genuine and stop worrying about group politics.

This verse also tells us that godly people who pray with passion are notable for how much they can accomplish. So you and I should both turn closer to God with strong emotions if we want our prayers answered.

5) Psalm 34:17 – Be Humble

The righteous cry, and the LORD hears and delivers them out of all their troubles.

Psalm 34:17 (NASB)

God is with us always and will help you during your trials and tribulations if you are with Him.

Think of Moses when he basically cried out to God and said that he wasn’t going to take another step in the desert unless God took it with him.

Be humble–not proud.

He loves it when we realize that we can’t walk our path alone and call out to Him for help. Then He shows up because that’s what Father’s do.

6) Jeremiah 29:12 – You’re in the Family Business

Then you will call on Me and come and pray to Me, and I will listen to you.

Jeremiah 29:12 (NASB)

God allow us to participate in His plans through prayer. We’re part of the family business and have God’s ear.

There’s nothing superficial about being able to communicate directly with the Creator of the universe—take it serious.

7) Matthew 21:22 – Pray with Expectation

And all things you ask in prayer, believing, you will receive.

Matthew 2:22 (NASB)

Believing is the key word in this passage. This means to feel sure of the truth or to accept it as being true.

The passage is telling us to believe that results are on the way if you ask God for something in prayer that will bring Him glory or display His glory.

Jesus didn’t do anything for scoffers because they didn’t believe in Him.

8) Mark 11:24 – Flex Your Faith Muscle

Therefor I say to you, all things for which you pray and ask, believe that you have received them, and they will be granted you.

Mark 11:24 (NASB)

This Scripture is similar to the last one except that it uses language in the past tense. Have so much faith in God that you believe it’s already a done deal.

Most of us probably struggle with this because we always want to see everything before we believe it.

Eternal prayer perspective

God is telling to to go ahead and flex your faith muscle for His glory.

9) Romans 12:12 – Prayer is not Seasonal

…rejoicing in hope, persevering in tribulation, devoted to prayer…

Romans 12:12 (NASB)

It looks like Paul is telling you to pray through the good times and pray through the bad times.

God is with us and listens regardless of our situation in life—He’s with you through all of it.

So rejoice and persevere with devotion in prayer.

10) Psalm 145:18 – Seek the Truth

The LORD is near to all who call on Him, to all who call on Him in truth.

Psalm 145:18 (NASB)

Salvation is the foundation of wisdom, and the opposite of being wise is being foolish. The truth is often controversial, but that doesn’t mean it’s not true.

Fools reject the truth, and salvation is only possible through Jesus. This is why Christians pray in the name of Jesus.

Jesus is all over the Old Testament, so we need to approach God in prayer as followers and servants of His son Jesus if we expect an answer.

11) Colossians 4:2 – Be Courageous and Dialed In

Devote yourselves to prayer, keeping alert in it with an attitude of thanksgiving;

Colossians 4:2 (NASB)

Paul is telling us to be more than just persistent in this passage, but all of it wouldn’t fit in one headline.

He’s is saying that you need to keep an eye out for specific needs that you can bring to God in prayer. Stay on top of what’s going on so that you have specific things to pray about instead of just being vague.

So pray for Joe and his family that lives down the street if he loses his job instead of the needy in general. Walk down and offer him some cash to help, and tell them the Lord sent you.

I struggle with this as someone who prefers the introverted cave life, but this will bless them and you by triggering the principles of reaping and stewardship at the same time.

God gave us dominion over our environment, so we should flex it for His glory.

12) 1 John 5:14-15 – Ask According To His Will

This is the confidence which we have before Him, that, if we ask anything according to His will, He hears us. And if we know that He hears us in whatever we ask, we know that we have the requests which we have asked from Him.

1 John 5:14-15 (NASB)

We can expect our prayers to be heard and answered when we pray to what He would want instead of what we desire.

Prayer depends on obedience to His commandments and avoiding sin.

Pray in obedience.

This Scripture also says that He always hears your prayers—just not always in the way you present it to Him.

Our Father is not a personal vending machine and doesn’t live in a bottle that we can rub for free wishes. We’re called to be a light to the world and a conduit for His desires.

13) Luke 18:1 – Pray Through the End

Now He was telling them a parable to show that at all times they ought to pray and not to lose heart,

Luke 18:1 (NASB)

Jesus tells us to keep praying as times get tougher and we see the approaching judgement coming to this world.

Don’t give up. Don’t let up. Keep looking up.

14) Ephesians 6:18 – Use The Full Power of Prayer

With all prayer and petition pray at all times in the Spirit, and with this in view, be on the alert with all perseverance and petition for all the saints…

Ephesians 6:18 (NASB)

15) Psalm 17:6 – Pray with Confidence

I have called upon You, for You will answer me, O God; Incline Your ear to me, hear my speech.

Psalm 17:6 (NASB)

Praying is not the same as publishing a blog post and wondering if anyone will ever read it.

If you belong to Jesus—God hears you. Know it without doubt. Him hearing us is the reason we pray to Him. Why else would we do it?

So pray with confidence and know that you are being heard by your Father in Heaven. The previous 15 Bible verses tell us that prayer is the key to our relationship with God.

Let’s recap with a summary:

  • Beg with Joy
  • Submit to God
  • Have an Eternal Perspective
  • Be Honest & Open
  • Be Humble
  • You’re in the Family Business
  • Pray with Expectation
  • Flex Your Faith Muscle
  • Prayer is not Seasonal
  • Seek the Truth
  • Be Courageous and Dialed In
  • Ask According To His Will
  • Pray Through the End
  • Use The Full Power of Prayer
  • Pray with Confidence

I used the MacArthur Study Bible for all of these verses. You can grab your own copy using this link.

May your prayers be fruitful and effective. Godspeed.

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